Napoleone ferrara biography definition

Ferrara has authored over scientific publications. Opens in a new window Opens an external site Opens an external site in a new tab. Napoleone Ferrara. Share this profile. View all winners. The work: Blood vessels are the part of the circulatory system that transports blood throughout the body and also play a vital role in virtually every medical condition.

Retrieved 25 September Fondation Lefoulon-Delalande Institut de France. Retrieved 12 December Breakthrough Prize laureates. Spielman Simon Brendle Shor John Cardy and Alexander Zamolodchikov HallRobert S. LangerRichard P. ElledgeHarry F. Cleveland C. Frank Bennett and Adrian R. Angiogenesis-dependent and independent phases of intimal hyperplasia.

Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. J Clin Endocrinol Metab. Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation.

Capillary regression in vascular endothelial growth factor-deficient skeletal muscle. Physiol Genomics. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. VEGFA is necessary for chondrocyte napoleone ferrara biography definition during bone development.

Ann N Y Acad Sci. Down syndrome critical region protein 1 DSCR1a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Biochim Biophys Acta. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost.

Vascular endothelial growth factor as a target for anticancer therapy. Trends Cardiovasc Med. LeCouter J, Ferrara N. The hypoxic response of tumors is dependent on their microenvironment. Curr Biol. Differential expression of the angiogenic factor genes vascular endothelial growth factor VEGF and endocrine gland-derived VEGF in normal and polycystic human ovaries.

Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. The biology of VEGF and its receptors. Diabetic patients and retinal proliferation: an evaluation of the role of vascular endothelial growth factor VEGF.

Exp Clin Endocrinol Diabetes. Exp Cell Res. HIF-1alpha is essential for myeloid cell-mediated inflammation. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.

The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med Berl. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol. Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer.

Endocrine gland vascular endothelial growth factor EG-VEGF and the hypothesis of tissue-specific regulation of angiogenesis. Endocr Res. VEGF and the quest for tumour angiogenesis factors. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover.

Napoleone ferrara biography definition: Ferrara is a world-renowned molecular biologist

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. Semin Cell Dev Biol.

VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells. J Magn Reson Imaging. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis.

J Virol. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol.

Napoleone ferrara biography definition: Napoleone FERRARA, Professor | Cited by

Ferrara NGerber HP. VEGF: an update on biological and therapeutic aspects. Curr Opin Biotechnol. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. A reassessment using novel receptor-specific vascular endothelial growth factor mutants. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor. Am J Obstet Gynecol. VEGF regulates cell behavior during vasculogenesis. A repressor sequence in the juxtamembrane domain of Flt-1 VEGFR-1 constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration.

Angiogenesis and bone growth. Formation of endothelial cell networks. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res. Clinical applications of angiogenic growth factors and their inhibitors.

Ferrara NAlitalo K. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration.

Toxicol Pathol. Molecular and biological properties of vascular endothelial growth factor. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. VEGF is required for growth and survival in neonatal mice. Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor VEGF.

Shi YP, Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol. Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans. Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization.

Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells.

Napoleone ferrara biography definition: Napoleone Ferrara, of the University of

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells. Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo.

Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Invest. The dormant in vivo phenotype of early stage primary human melanoma: termination by overexpression of vascular endothelial growth factor.

Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Vascular endothelial growth factor attenuates myocardial ischemia-reperfusion injury. Ann Thorac Surg. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes.

The biology of vascular endothelial growth factor. Ferrara NDavis-Smyth T. Vascular endothelial growth factor: basic biology and clinical implications. Ferrara NKeyt B. Inhibition of vascular endothelial cell growth factor suppresses the in vivo growth of human prostate tumors. Urol Oncol. Eur J Cancer. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma.

Crystallization of the receptor binding domain of vascular endothelial growth factor. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. John Croxall. Ronald M. Michael A. Hans Kornberg. Ignacio Solano.

Napoleone ferrara biography definition: Napoleone Ferrara - Distinguished Professor

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